We are biomedical optics lab using lasers for the observation of cells in vivo, the sensing of metabolic molecules, the diagnosis of diseases, and the development of medical devices. For the observation, we integrated home-build femtosecond lasers, scanning electronics, and microscopes into an in vivo microscopy system. On this platform, we studied embryonic development, tumor microenvironment, pharmacokinetics of nanomedicines, and in vivo cytometry of leukocytes. For the tracking of cells or drug delivery, we developed multiphoton contrast agents with nanomaterials like Si quantum dots, gold nanorod-in-shell, insulin-gold nanodot, iron oxide, and iron-platinum alloy. Exploiting the laser excited autofluorescence of metabolic molecules, we are developing spectroscopic methods for disease diagnosis. Through the discovery of characteristic optical properties in biomedical context, we aim to develop medical devices to solve the unmet clinical needs.

June 24, 2022

  A monograph of Tzu-Ming LIU has been published by American Institute of Physics Publishing.

July 1, 2021

Vessel penetrating phosphorescence probes bind collagen to report tissue oxygenation in vivo (Advanced Science volume 8, 2102788, 2021)

May 29, 2019

The third harmonic generation angiography with FeOOH materials has been selected as the back cover story of the journal Small  (Vol. 15, Issue 20, 2019).

September 22, 2018

Medical device team CATYDID from Tzu-Ming LIU's Lab won the silver prize in 2018 Guangdong Entrepreneurship and Innovation Competition

April 25, 2017


The milestone paper of the Lab reviews the design thinking of laser sources, imaging methods, and nano materials for the theranosics of cancer.

August 15, 2016

Lab leader, Tzu-Ming Liu, moves from Institute of Biomedical Engineering, National Taiwan University to Faculty of Health Sciences, University of Macau.

December 25, 2015


Tzu-Ming Liu led medical device team Morcellbag win the potential startup award.

November 23, 2014


Tzu-Ming Liu led medical device team EpiFaith to win the Excellent Startup Awards of FITI, Taiwan.

June 10, 2014

New website launched! Please feel free to let us know what you think.


Tel: +853-8822-4693

Email: [email protected]

    • National Taiwan University
    • Chi-Kuang Sun / Pi-Tai Chou / Pai-Chi Li
    • Fu-Hsiung Chang / Win-Li Lin
    • Shi-Wei Chu / Jean-San Chia
    • National Taiwan University Hospital
    • Tzung-Dau Wang /Wen-Jeng Lee
    • Yao-Ming Wu / Chia-Yu Chu / I-Rue Lai
    • National Cheng Kung University
    • Dar-Bin Shieh / Chen-Sheng Yeh
    • National Yang-Ming University
    • Chih-Chia Huang
    • Academia Sinica
    • Huan-Cheng Chang / Yu-Ju Chen
    • Massachusetts General Hospital
    • Charles Lin
    • Cornell University
    • Chris Xu